Reeler domain

Reeler domain
Identifiers
Symbol Reeler
Pfam PF02014
InterPro IPR002861

Reeler domain is a protein domain.

Extracellular matrix (ECM) proteins play an important role in early cortical development, specifically in the formation of neural connections and in controlling the cyto-architecture of the central nervous system. The product of the reeler gene in mouse is reelin, a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment.[1] F-spondin and mindin are a family of matrix-attached adhesion molecules that share structural similarities and overlapping domains of expression. Both F-spondin and mindin promote adhesion and outgrowth of hippocampal embryonic neurons and bind to a putative receptor(s) expressed on both hippocampal and sensory neurons.[2]

This domain of unknown function is found at the N terminus of reelin and F-spondin.

Examples

Human genes that encode proteins containing the reeler domain include:

FRRS1, RELN, SPON1

References

  1. ^ Cooper JA, Nakajima K, Mikoshiba K, Curran T, Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Howell BW, Goldowitz D (1997). "Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice". Nature 389 (6652): 730–733. doi:10.1038/39601. PMID 9338784. 
  2. ^ Okamoto H, Higashijima S, Garcia C, Feinstein Y, Borrell V, Burstyn-Cohen T, Tzarfaty V, Frumkin A, Nose A, Soriano E, Klar A (1999). "F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons". Development 126 (16): 3637–3648. PMID 10409509. 

This article incorporates text from the public domain Pfam and InterPro IPR002861